EFFICIENT ROUTING PROTOCOL ALGORITHM FOR WIRELESS SENSOR NETWORKS

Recently, different applications of wireless sensor networks (WSNs) in the industry fields using different data transfer protocols has been developed. As the energy of sensor nodes is limited, prolonging network lifetime in WSNs considered a significant occurrence. To develop network permanence, researchers had considered energy consuming in routing protocols of WSNs by using modified Low Energy Adaptive Clustering Hierarchy. This article presents a developed effective transfer protocols for autonomic WSNs. An efficient routing scheme for wireless sensor network regarded as significant components of electronic devices is proposed. An optimal election probability of a node to be cluster head has being presented. In addition, this article uses a Voronoi diagram, which decomposes the nodes into zone around each node. This diagram used in management architecture for WSNs

Estimation of Bone Marrow DNA Damage Induced by Lambda cyhalothrin and Dimethoate Insecticides using Alkaline Comet Assay

Dimethoate (DM) and Lambda cyhalothrin (LCT) are commonly used insecticides. Human being and farm animals are expected to have acute toxicity. The present work aimed to explore the effect of acute exposure to DM and LCT on hematological parameters and to detect DNA damage in bone marrow of Sprague Dawley rats using the alkaline single cell gel electrophoresis assay (comet assay). Thirty animals were divided into three groups of ten rats each. LCT group administered 26 mg/kg body weight, DM group administered 103 mg/kg body weight orally for 24 and 48 hours, while the control group received the vehicle only. Blood samples were collected for hematological analysis, bone marrow was flushed from the femur bone for comet assay and spleen samples were preserved in formalin for histopathological examination.  Results showed minor changes in blood profile in all exposed groups associated with mild changes in histology of spleen tissue. Alkaline single cell gel electrophoresis assay in bone marrow cells showed that LCT and DM caused extensive and severe DNA damage after 48 h exposure expressed as significant increases in all comet parameters (% DNA in tail, tail length, tail moment and Olive tail moment). The results concluded that LCT and DM induced DNA damage in bone marrow of rats, LCT showed higher degree of DNA damage in comparison with DM

Enhancing User Authentication with Facial Recognition and Feature-Based Credentials

This research proposes a novel and trustworthy user authentication method that creates individualized and trusted credentials based on distinctive facial traits using facial recognition technology. The ability to easily validate user identification across various login methods is provided by this feature. The fundamental elements of this system are face recognition, feature extraction, and the hashing of characteristics to produce usernames and passwords. This method makes use of the OpenCV library, which is free software for computer vision. Additionally, it employs Hashlib for secure hashing and Image-based Deep Learning for Identification (IDLI) technology to extract facial tags. For increased security and dependability, the system mandates a maximum of ten characters for users and passwords. By imposing this restriction, the system increases its resilience by reducing any possible weaknesses in its defense. The policy also generates certificates that are neatly arranged in an Excel file for easy access and management. To improve user data and provide reliable biometric authentication, this study intends to create and implement a recognition system that incorporates cutting-edge approaches such as face feature extraction, feature hashing, and password creation. Additionally, the system has robust security features using face recognition

Correlation between Anti cyclic-citrullinated-‎eptide and rheumatoid Factor Antibodies ‎‎“levels in” Patients with from Rheumatoid ‎Arthritis

للتعرف على استخدام الانتي سايكلك للبروتين سيتروليناتد ببتايد  والعامل الروماتزم ونسبة ترسيب كريات الدم الحمراء في تشخيص المرضى المصابين بالروماتزم الرثياني. جمعت  خمسين عينه لمرضى مصابين بالروماتزم الرثياني  من قسم الامراض الثيانيه في مدينة الصدر الطبية التعليميه , حدوث نسبة مستوى عامل الروماتزم  والانتي سايكلك سيتروليناتد ببتايد  بطريقة الامتزاز المناعي المرتبط بالانزيم , بينما تم  قياس نسبة ترسيب الخلايا الحمراء بطريقة الويستركرين. بينت الدراسه بأن نسبة توزيع المرضى المصابين بالروماتزم في النساء اكثر من الرجال 80%, 20% بالتتابع حسب مجاميع المرضى. قسمت المرضى الى ثلاث مجاميع حسب العمر  أقل من (30),  (30 – 50) وأكثر من (50)  أظهرت نسبة هذه المجاميع كالتالي 16%, 52% , و 32%  كما بينت الدراسه بأن نسبة (49) 98%  كان لديهم فحص موجب للانتي سايكلك ستروليناتد ببتايد ونسبة (22) 44% لديهم فحص لعامل الروماتزم و نسبة (37) 74% كان لديهم ارتفاع في مستوى ترسيب كريات الدم الحمراء.  أخيرا̋ أظهرت النتائج بأن متوسط القيم للانتي  سايكلك ستروليناتد ببتايد وترسيب كريات الدم الحمراء كان عالي المنويه (0.05 P< )  بينما اظهرت النتائج ارتفاع معنوي في مستوى عامل الروماتزم. لذلك فأن استخدام سايكلك ستروليناتد ببتايد  يعتبر فحص مفيد لتشخيص الروماتزم, وكذلك استخدام عامل  الروماتزم  والانتي سايكلك ستروليناتد ببتايد  ممكن ان يعطي قيمة تشخيصيه للروماتزم الرثياني.To  identify  diagnostic   utilities  of   Anti   citrullinated   protein   (ACCP)   and Rheumatoid   factor  (RF)   are  autoantibodies (Abs  directly  against an self-individual antigens),  Analytical  study.  The  questioner  reported  for  50  patients  with  RA were collected  from  Department  of  Rheumatology¸  AL˗Sader  Teaching  Hospital.  Serum levels  of  RF & (ACCP)  Abs  were  determinated  by enzyme ˗ linked immunosorbent assay”, while  the  level  of  erythrocyte  sedimentation  rate  (ESR)  was determined by westergreen  method.   Distribution  of  RA occur  in  females  more  than  males which  reached  (80%)  &  (20%)  respectively  according  to  the  patients group. The patients divided  according  to the  age  into  three  groups (<30)¸ (30˗50) &  (>50). The  percent for  these  groups  were  (16%)¸ (52%) & (32%). Among the 50 patients with RA¸ CCP and  ESR  49  patients  (98%)  tested  positive  for  (ACCP)  antibodies¸ and 22 patients (44%)  tested  positive for RF. and 37  patients(74% ) tested increasing levels of ESR in RA  patients. The  mean  value of (ACCP) & ESR shows highly significance  (P<0∙05), while the  RF serum  levels increase significantly. Demonstrate  the (ACCP) antibodies assay is a useful test for diagnosing RA. However, the use of RF and (ACCP)auto- antibodies  in  combination  further  elevated   the diagnostic  value  for  R

Diagnostic evaluation of blunt abdominal trauma scoring system (BATSS)

Background: Blunt force abdominal trauma is a typical emergency room presentation in both adults and children. Trauma is widely acknowledged as one of the primary causes of illness and mortality in poor nations, as well as the greatest cause of death in those under the age of 45.Objectives: This study aims to study the diagnostic evaluation of blunt abdominal trauma scoring system (BATSS) in patients with blunt abdominal trauma in Zagazig University Hospital.Patients and methods: This study was conducted on 48 patients suffering from blunt abdominal trauma in Emergency Department of Zagazig University Hospital from January 2021 to June 2021.Result: The mean age of patients in the study was 25.87±10.7 years (range 17–61 years). Of the forty eight patients in the study there were 13 females (27.1%) and thirty five males (72.9%).There was statistically significant difference between blunt abdominal trauma scoring system (BATSS) and types of injury p<0.001. There was no statistically significant difference between blunt abdominal trauma scoring system (BATSS) and each of patients' sex and causes of injury p>0.05. Conclusion: The BATSS score system can be used as an initial screening to predict blunt abdominal trauma outcome and can be the basis of management in patients who experience blunt abdominal trauma

Dry Weight Assessment in Children on Regular Hemodialysis with Special Relation Between Acute and Chronic Renal Failure

Background: Adequate assessment of fluid status is an imperative objective in the management of HD patients. An inaccurate assessment of dry weight leads to many complications. Objective: The aim was to assess applicability of clinical using inferior vena cava (IVC) and lung ultrasonography to assess dry weight and the adequacy of fluid removal in hemodialysis children with special relation between acute and chronic renal failure. Patients and methods: 75 children were classified into two groups: Group (1): Chronic renal failure and group (2): Acute renal failure.Results: A statistically positive significant correlation between percent of weight loss after dialysis among the studied patients and all of serum ferritin, creatinine, phosphorus and iron. There was statistically negative significant correlation between percent of weight loss after dialysis among the studied patients and serum creatinine. There was statistically significant negative correlation between percent of weight loss after dialysis among the studied patients and SPAP. There was statistically non-significant correlation between percent of weight loss after dialysis among the studied patients and percent change in IVC inspiratory diameter, expiratory diameter, collapse index and B lines. There was statistically significant difference between the studied groups and expiratory IVCD, collapse index before and after dialysis, difference in B lines. Conclusion: Lung ultrasound is an accurate and sensitive method of quantifying subclinical fluid overload in children on dialysis before its clinical manifestation. IVC measurement is reliable to assess intravascular fluid overload in children on HD and was not correlated with extracellular fluid volume as need more time (2-3h) after dialysis and maneuver difficult with young age

Dietary clenbuterol modifies the expression of genes involved in the regulation of lipid metabolism and growth in the liver, skeletal muscle, and adipose tissue of Nile tilapia (Oreochromis niloticus)

The current study aimed to evaluate whether clenbuterol, a β2-adrenergic agonist, supplementation in Nile tilapia (Oreochromis niloticus) diets can influence growth and blood parameters. Besides, assessment of adipogenic genes as fatty acid synthase (FAS) and lipoprotein lipase (LPL) which is a key enzyme in the regulation of the flux of fatty acids in liver, muscle, and adipose tissue as well as muscle growth-regulating genes as myostatin (MYO) in muscle and insulin-like growth factor-1 (IGF-1) in liver. The fish were allocated into three equal groups; control group that fed basal diet only and the other two groups fed a basal diet containing clenbuterol at two doses 5 ppm and 10 ppm/kg diet for 30 consecutive days. Results revealed that clenbuterol supplementation significantly increased body weight, decreased liver, spleen and abdominal fat weights, and decreased total circulatory cholesterol and triacylglycerol levels. Moreover, clenbuterol inhibits lipogenesis by downregulation of FAS gene expression by dose and time-dependent manner in the liver while enhanced lipolysis in both the liver and in the adipose tissue. Moreover, lipolysis was reduced in muscle by dose 10 ppm on day 30. Furthermore, clenbuterol presented higher gene expression of MYO and IGF-1 in muscle and liver respectively by dose 5 ppm at day 15 on the other hand, these findings were reversed by day 30 compared with control. In conclusion, clenbuterol efficacy was apparent in a dose and time response pattern to boost growth and reduce fat deposition rates, indicating for the first time that clenbuterol has a profitable growth impact on Nile tilapia

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types